Vascular endothelial growth factor in the lung.

نویسندگان

  • Norbert F Voelkel
  • R William Vandivier
  • Rubin M Tuder
چکیده

Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor that has a broad impact on endothelial cell function. The lung tissue is very rich in this protein; many different lung cells produce VEGF and also respond to VEGF. VEGF is critical for the development of the lung and serves as a maintenance factor during adult life. In addition to the physiological functions of this protein, there is increasing evidence that VEGF also plays a role in several acute and chronic lung diseases, such as acute lung injury, severe pulmonary hypertension, and emphysema. Here we provide a comprehensive overview of the rapidly expanding literature.

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عنوان ژورنال:
  • American journal of physiology. Lung cellular and molecular physiology

دوره 290 2  شماره 

صفحات  -

تاریخ انتشار 2006